Tele-rehabilitation has recently emerged as an effective solution for providing assisted living, increasing clinical outcomes, positively enhancing patients’ Quality of Life (QoL) and fostering their reintegration into society, also pushing down clinical costs. Cloud computing in combination with Edge Computing, the Internet of Things (IoT), Big Data storage and analytics, and Artificial Intelligence (AI) are the main enablers for tele-rehabilitation. In this paper, we present the Italian founded PRIN 2022 project entitled “Tele-rehabilitation as a Service (TRaaS)”. It aims at creating a piece of reference intelligent Cloud/Edge framework architecture and a standard data model for the development of different kinds of new de-hospitalized tele-rehabilitation services. In particular, the rationale, study design, and methodology are discussed, also highlighting future research directions.