process of Mobile Information Systems.$ is special issue is motivated by recent advances in mobile health. Indeed, Internet-of-things (IoT) is changing eHealth and especially mobile Health (m-Health) systems. Currently, more and more fixed and mobile medical devices are installed in patients’ personal body networks and medical devices, and the surrounding clinical/home environments collect and send a huge amount of heterogeneous health data to healthcare information systems for their analysis. In this context, machine learning and data mining techniques are becoming extremely important in many reallife problems. Many of these techniques have been developed for health data processing and analysis on mobile devices. Several mobile applications based on these techniques have emerged as an essential technology for improving the quality of medical diagnosis and treatments of many illnesses as well …